TreVeyon Henderson's Ankle Puts Rhamondre Stevenson Back in Charge After Drake Maye's Five-Touchdown Day

New England Patriots running back TreVeyon Henderson injured his right ankle in the second quarter of Sunday's 45-17 win over the Las Vegas Raiders and was ruled out for the rest of the game. Left tackle Will Campbell went down with a knee injury within the same stretch of plays, with initial reports describing it as a believed sprain and an MRI scheduled for Monday.

The win was a showcase for Drake Maye, who completed 26 of 34 passes for 374 yards and four touchdowns, added a rushing score and did not turn the ball over. But the injuries to Henderson and Campbell are the story fantasy managers need to act on before Week 6, when the Patriots host the New York Jets.

What happened

Henderson had four carries for 22 yards and one catch before leaving. The Patriots did not announce a timeline after the game, and the history here is what makes managers nervous: Henderson missed most of August and the start of the regular season with injuries before returning in Week 2, and this is another setback in a season that has rarely let him settle in.

Campbell's injury is arguably just as important for the offense. Campbell, a first-round pick in 2025, protects Maye's blind side, and any extended absence would push a backup into a premium spot. The MRI on Monday should answer whether this is a short-term sprain or something longer.

The Patriots' Sunday in numbers

New England's win was as complete as a 45-17 score suggests. The key lines for fantasy purposes:

The Patriots are 3-2 and have won two straight. The Raiders fell to 3-2 with their second consecutive loss, and Fernando Mendoza made his NFL debut late in the blowout.

Fantasy fallout in New England

Rhamondre Stevenson is the immediate winner. He opened the season as the lead back while Henderson was out, and Rotowire and other fantasy outlets expect him to function as the workhorse if Henderson misses time. Stevenson's value is volume-driven: he is an RB2 in Week 6 against the Jets if Henderson is ruled out, with goal-line work in an offense that just scored 45 points.

Corey Kiner is the likely No. 2 back behind Stevenson. He is a deep-league handcuff, not a starter.

TreVeyon Henderson managers should hold. Ankle injuries vary wildly in severity, and there is no confirmed timeline. Bench him until he practices.

Drake Maye is a locked-in QB1 after a performance like this, but watch the Campbell MRI. A downgrade at left tackle matters more for a quarterback than for any other position, and it is the main risk to Maye's floor in the weeks ahead.

The Raiders side

Ashton Jeanty's day was the low point of Las Vegas's afternoon. He was questionable going into the game, and he managed just 27 rushing yards on 10 carries, salvaging some value with three catches for 50 yards. A lopsided game script ruined his volume. He remains a weekly RB1 by role, and a blowout loss does not change that, but his questionable tag going into Sunday is worth monitoring when practice reports return on Wednesday.

Brock Bowers was the Raiders' best weapon again, catching eight passes for 110 yards and a score. In negative game scripts, Bowers' target share only rises. Las Vegas hosts the Buffalo Bills in Week 6, a tougher defensive test, but Bowers is matchup-proof as a top tight end and should be started without hesitation.

The Verdexed angle

The Week 6 game against the Jets is a division matchup where New England's offensive health is the main variable. If Stevenson is the lead back and Campbell is limited or out, the Patriots' formula likely shifts toward quicker throws and a steadier run game. That has implications for the total as much as the side.

For the model's view of Jets at Patriots, see the NFL predictions page and the Week 6 picks once they publish. Bettors should treat the Campbell MRI as the single most important piece of information for this line, ahead of Henderson's status. Running backs are replaceable in a game line; a left tackle protecting a quarterback playing at this level is not. The Jets will also have a full week to plan for an offense that put up 45 points, which is the other reason to expect the total to be one of the more debated numbers of the Sunday early window.

What to do in your league

1. Add Rhamondre Stevenson wherever he is available, and start him as an RB2 in Week 6 if Henderson is out. 2. Hold Henderson. Wait for Wednesday's practice report before deciding anything. 3. Keep starting Maye, but check the Campbell news Monday afternoon. A long absence lowers his floor, not his ceiling. 4. Do not panic on Jeanty. One blowout does not define a season-long workhorse. 5. Consider Corey Kiner only in deep leagues or as a direct Stevenson handcuff.

New England's offense looked like a top-tier unit on Sunday. The question for fantasy managers this week is who gets the ball in the backfield, and the answer, at least for now, is Stevenson.